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Journal Highlights
The LINC complex depicted here transfers mechanical forces from the cytoskeleton across the nuclear envelope and into the nucleus. Small differences in the molecular structures of LINC complexes allow drastically different responses under force and may contribute to their diverse roles in various cellular functions. See the article by Jahed et al.
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This volume describes research methodologies and approaches used to study the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex and its cellular functions. Chapters detail structural and biochemical analysis of LINC complexes, mechanical aspects of the LINC complex, analysis of the LINC complex in model systems and development, and LINC complex in mammalian tissue, organs, and disease.
Includes Hennen et al., 2018 and Fridolfsson et al., 2018.
The study of the mechanobiology of the cell nucleus has become an active and fruitful area of research marrying numerous fields in an attempt to understand both how forces and biochemical signaling are coordinated to modulate genome activity and homeostasis and how defects in these processes may impact human disease pathogenesis.
Issue found here. Includes Dahl & Luxton, 2016 and Saunders & Luxton, 2016.
Includes Exploring the LINC to nuclear envelope spacing.
LINC complexes do not maintain the space between nuclear membranes, except in cells exposed to mechanical stress, reveal.
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Immunostaining of KDP-1 (green) and lamin (red) in a syncytial C. elegans hermaphrodite gonad. DAPI-stained nuclei are blue. The novel KASH protein KDP-1 localizes to the nuclear envelope where it functions to ensure progression of the cell cycle.
Issue found here.
featured papers
Current Biology.
GWG Luxton, DA Starr (2014), KASHing up with the nucleus: novel functional roles of KASH proteins at the cytoplasmic surface of the nucleus. Current Opinion in Cell Biology.